hCD44v9/4T1
CBPG0278
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| I. Background | |||
| CD44v9是CD44基因的可变剪接变异体，在多种上皮性肿瘤和肿瘤干细胞表面高表达。它顺利获得与xCT（胱氨酸/谷氨酸转运蛋白）相互作用，增强细胞内谷胱甘肽合成，清除活性氧，从而赋予肿瘤细胞抗氧化应激和耐药能力，并促进肿瘤侵袭、转移和复发。其高表达通常提示预后不良，是重要的肿瘤标志物和潜在治疗靶点。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hCD44v9 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+ 10μg/ml Blasticidin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
IV. Representative Data Figure 1.Recombinant hCD44v9/4T1 stably expressing hCD44v9. |
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