KIR2DL5A HEK293
CBP74612
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| I. Background | |
| KIR2DL5A是由KIR2DL5A基因编码的一种抑制性杀伤细胞免疫球蛋白样受体,属于KIR家族。它主要表达于自然杀伤(NK)细胞和部分T细胞亚群表面,其胞内区包含ITIM(免疫受体酪氨酸抑制基序),在与配体结合后能够招募磷酸酶并传递抑制性信号,负向调节NK细胞的杀伤活性。该受体的配体为非经典的HLA I类分子,参与机体免疫耐受的维持。此外,KIR2DL5A基因具有显著的等位基因多态性,其表达水平受启动子甲基化等表观遗传机制调控。 | |
| II. Description | |
| KIR2DL5A HEK293细胞,在 HEK293细胞的基础上,稳定表达KIR2DL5A 。 | |
| III. Introduction | |
| Expressed gene: | KIR2DL5A |
| Host Cell: | HEK293 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant KIR2DL5A HEK293 constitutively expressing KIR2DL5A. |
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